Co-culture of human pancreatic islets with human adipose-derived stromal/stem cells can improve islet quality in vitro
نویسندگان
چکیده
Background In patients with unstable type 1 diabetes mellitus (T1D), allogeneic pancreatic islet transplantation is a therapeutic option to restore insulin secretion and improve metabolic control. However, the success of islet transplantation is dependent on the number and quality of isolated islets. It is known that the inflammatory environment related to the donor’s brain-death (BD) and the stress induced during islet isolation reduces islet quality. Adipose-derived stromal/stem cells (ASC) are multipotent cells that release several trophic factors with anti-inflammatory and cytoprotective actions. Thus, in vitro co-culture of islets with ASCs may improve islet quality isolated from BD-donors, attenuating inflammation and apoptosis.
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